Certified Wound Ostomy Nurse (CWON) Practice Test

What concentrations of povidone-iodine are considered safe for use without harming fibroblasts?

1. 0.1% solution

2. 1% solution

3. 0.2% solution

4. 1% and lesser concentrations

The correct answer is: 1% and lesser concentrations

The safe use of povidone-iodine is critical in wound care due to its potential cytotoxic effects, particularly on fibroblasts that are essential for wound healing. Research indicates that concentrations less than 1% are generally considered safe for fibroblast activity. Povidone-iodine acts as an antimicrobial agent, but higher concentrations can inhibit collagen synthesis and delay wound healing by affecting the viability of fibroblasts. Specifically, a 1% solution and lesser concentrations are shown to maintain fibroblast functionality while providing the necessary antiseptic properties to prevent infection. Using a concentration above this threshold can lead to the cytotoxic effects that compromise healing processes. Hence, the correct answer indicates that both 1% and any lower concentrations of povidone-iodine are safe to use in wound care, emphasizing the importance of adhering to these guidelines to promote optimal healing outcomes.