Certified Wound Ostomy Nurse (CWON) Practice Test

What consequence may arise from an imbalance between the lysis and synthesis of collagen fibers?

1. Delayed healing and increased risk of infection

2. Hypertrophic or keloid formation

3. Reduced scar formation and quicker recovery

4. Infection and necrosis of surrounding tissues

The correct answer is: Hypertrophic or keloid formation

The consequence of an imbalance between the lysis and synthesis of collagen fibers is primarily the development of hypertrophic scars or keloids. Collagen plays a crucial role in wound healing, providing structural support and facilitating the repair process. During healing, the body synthesizes collagen to form a matrix for tissue repair, while lysis (breakdown) of collagen occurs to remodel and refine the tissue. When there is an excess synthesis of collagen that outpaces its breakdown, it can lead to an overproduction of scar tissue, resulting in hypertrophic scars that are raised and often painful. In more extreme cases, this imbalance may lead to keloids, which are larger and extend beyond the original boundaries of the wound. Such scars can lead to complications including discomfort and decreased cosmetic appearance, significantly affecting the patient's quality of life. The other choices, while related to wound healing, do not directly stem from the lysis and synthesis imbalance in collagen fibers to the same degree. Therefore, understanding this concept offers insight into proper management of wound healing and scar formation.