Certified Wound Ostomy Nurse (CWON) Practice Test

What is the function of protease (MMP) inhibitors in wound care?

1. To promote infection

2. To enhance water retention in dressings

3. To downregulate proinflammatory MMPs

4. To promote biofilm formation

The correct answer is: To downregulate proinflammatory MMPs

The function of protease (MMP) inhibitors in wound care primarily centers around their ability to downregulate proinflammatory matrix metalloproteinases (MMPs). MMPs play a significant role in the normal healing process; however, when present in excess, they can lead to excessive degradation of extracellular matrix components, which adversely affects the healing process. By inhibiting these MMPs, the inhibitors help maintain a balanced wound environment that encourages healing. This is particularly important in chronic wounds where MMP activity is often elevated. The downregulation of proinflammatory MMPs promotes a more favorable regenerative environment, thereby facilitating tissue repair and progression through the healing phases. The other functions of promoting infection, enhancing water retention in dressings, or promoting biofilm formation are not associated with the role of MMP inhibitors. Instead, these activities would typically hinder the healing process rather than enhance it.