Certified Wound Ostomy Nurse (CWON) Practice Test

Which factors are known to affect neoangiogenesis?

1. Diet, moisture level, and volume of wound

2. O2 levels in wound bed, hyperglycemia, and age

3. Infection, inflammation, and medication adherence

4. Temperature, hygiene, and patient motivation

The correct answer is: O2 levels in wound bed, hyperglycemia, and age

The factors that affect neoangiogenesis are significant because they play a crucial role in the healing processes of wounds. The correct selection highlights oxygen levels in the wound bed, the presence of hyperglycemia, and the age of the patient as key influencers of neoangiogenesis. Oxygen levels are critical because they are essential for the formation of new blood vessels, which supply necessary nutrients and facilitate the removal of waste products, thereby promoting healing. A well-oxygenated wound bed can enhance the proliferation of endothelial cells, which are vital for forming new vasculature. Hyperglycemia negatively impacts vascular health and wound healing by creating an unfavorable environment for angiogenesis. Elevated glucose levels can lead to increased oxidative stress and the production of advanced glycation end products (AGEs), which can inhibit the normal function of endothelial cells. Age also plays a role in neoangiogenesis; older adults often experience impaired angiogenic responses due to a variety of factors, including decreased cellular proliferation and changes in the microenvironment that affect healing. The other options do mention important factors related to wound healing; however, they do not directly relate to the processes of neoangiogenesis as clearly as the factors in the correct answer. For instance, while diet and moisture level can influence wound healing