Certified Wound Ostomy Nurse (CWON) Practice Test

Which of the following layers contains desmosomes for cell-to-cell junctions?

1. Stratum lucidum

2. Stratum germinativum

3. Stratum granulosum

4. Stratum spinosum

The correct answer is: Stratum spinosum

The stratum spinosum is the correct choice because it is characterized by the presence of desmosomes, which are specialized structures that facilitate cell-to-cell adhesion. These junctions are crucial for maintaining the integrity and structure of the epidermis. In this layer, keratinocytes appear spiny due to the contraction of the cells during tissue preparation, exposing the desmosomal connections. This layer acts as a robust barrier against mechanical stress and contributes to the overall resilience of the skin. In contrast, the stratum lucidum is primarily found in thick skin areas like the palms and soles, and it serves as a clear layer that provides extra protection but does not have a high density of desmosomes. The stratum germinativum, also known as the basal layer, is primarily composed of basal cells that undergo mitosis and does not predominantly feature desmosomes for cell-to-cell junctions compared to the spinosum. The stratum granulosum contains keratinocytes that are transitioning into a more keratinized state and focuses on the formation of keratin and lipid-rich lamellar bodies, rather than on strong cell-to-cell junctions. Thus, the presence of desmosomes is distinctively noted in the stratum spinos